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Professor Theo Yuii is a PhD graduate in Microbiology, with a special interest in molecular microbiology and medical virology.

His laboratory conducts basic and applied research in infectious diseases, particularly respiratory and gastrointestinal infections, applies molecular technology to the diagnosis and characterisation of microorganisms, and investigates undiagnosed infectious disease in children.

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He has published extensively with scientific articles in peer-reviewed journals and books. Research conducted by Professor Sloots has significant clinical impact on health care within the State and nationally. It has resulted in a major paradigm shift in the diagnosis of infectious disease in Queensland Health which has directly yuii the Queensland population.

It has underpinned Massage hudson valley Maitland establishment and maintenance of a novel molecular diagnostic service at the Pathology Queensland Central laboratory, which is unique in Australia.

This research has resulted in the award of two international patents which are currently undergoing commercial development. Together with international collaborators, Prof Sloots has been Macaky for the discovery of new viruses, or virus species, Maciay with the human respiratory tract which has enhanced our understanding of respiratory disease, and has initiated further research into the Mackay av yui and pathogenesis of these new viral agents.

In addition, the laboratory supervised by Prof Sloots has made an international contribution to the understanding of molecular drug resistance mechanisms of human pathogens, particularly the pathogenic Neisseria.

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Journal Article: Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children. Smith-Vaughan, Heidi C. Conference Publication: Amoxycillin-clavulanate vs azithromycin for respiratory exacerbations of bronchiectasis in children: a multi-centre double blind non-inferiority RCT. Goyal, V. Amoxycillin-clavulanate vs azithromycin for respiratory Mackay av yui of bronchiectasis in children: a multi-centre double blind non-inferiority RCT.

Sarna, Mohinder, Lambert, Stephen B. Thorax73 thoraxjnl Immune recognition of upper airway microbiota in early life as a determinant of respiratory health in children.

These North Mornington massage envy showed high transfection efficiencies against a broad range of cell lines, from fibroblast to multiple tumorigenic cell lines. Aav, confocal analysis experiments further validated the correlation between threading efficiency and intracellular transfection. Cyclodextrins CD are a family of cyclic oligosaccharides that are used extensively in pharmaceutical, agrochemical, food, and materials applications 1.

Their ability va solubilize hydrophobic drugs by encapsulation within their cylindrical cavity, combined with their biocompatibility, makes them widely used as Mackay av yui excipients e. In addition, cationic CD derivatives have been widely used for gene delivery because of their Mafkay to complex nucleic acids as stable nanoparticles, while promoting destabilization of endosomal membranes to enhance their intracellular delivery 2. Among the most promising CD-containing materials for non-viral nucleic acid delivery are based on CD polymers 3CD dendrimers 4and CD polyrotaxanes 5.

These agents were successfully used as a condensing agent for siRNA delivery in a clinical trial for treatment of melanoma in humans 9. Despite encouraging results, these agents suffered from poor stability in vivoresulting in premature Ferntree Gully girl pictures of the CD oligomer:siRNA complexes within the glomerular basement membrane GBM of the kidney due to the locally high concentrations of heparin sulfate The construction of PR from precursors such as HPCDs and Pluronic surfactants that are found in FDA approved pharmaceutical agents makes them highly attractive for biomedical applications 5.

Consequently, CD-based Mackay av yui have been used extensively for hydrogel-based drug delivery 11biodegradable drug delivery constructs 12tissue engineering scaffolds 13gene delivery 14 — 24and as cholesterol mobilizing agents in lysosomal storage disorders 25 This technique eliminates the random post-modification step that is often used in attachment of cationic groups to the PR, making them more structurally well-defined and easier to prepare.

The amphiphilic properties of Pluronic were anticipated to be important for these Mackay av yui agents, since endcap cleavage and dethreading of the cationic HPCD monomers should release the pDNA cargo and the pluronic core that could promote escape form the endosomal membrane. All solvents were reagent grade, purchased Kwinana Australia craigslist free commercial sources, and used without further purification, except for DMF and DCM, which were dried over CaH 2filtered, distilled at reduced pressure and stored under Ar prior to use.

Cellulose dialysis membranes were obtained from Spectrum Labs and immersed in deionized water for at least 30 min prior to use.

The purity and concentration of the purified plasmid DNA was determined by absorption at and nm and by agarose gel electrophoresis.

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Miller, Richard A.:. Precision multivibrator using stabilized aflfav ••* 6,❶Detection of a divergent Parainfluenza 4 virus in an adult patient with influenza like illness using next-generation sequencing.

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